![]() There were significant between-group differences in the astigmatism axis, asphericity coefficient, and intraocular pressure in favor of the DHA group. A panel of fatty acids in blood samples was also assessed. Corneal topography variables and plasma biomarkers of oxidative stress and inflammatory status were evaluated. Thirty-four patients were recruited (75% men, mean age 31 years), with 15 randomized to the control group and 19 to the DHA-treated group. Simply exchanging a common insulinogenic bread for a low-insulin-stimulating bread demonstrates potential to induce weight loss in overweight persons, especially those at older age.Ī prospective, randomized, single-center preliminary study was performed in patients with keratoconus stages I–III (Amsler–Krumeich), who received a high rich docosahexaenoic acid (DHA) (1000 mg/day) supplement for 3 months versus untreated patients. No other statistically significant changes in clinical or lifestyle parameters were noted. Moreover, in the intervention group, the percentage of participants with significant weight loss (≥1 kg) was twice as high as in the control group ( p < 0.001). ![]() Whereas body weight remained unchanged in the control group (−0.1 ± 2.0 kg), significant weight reduction was observed in the intervention group (−1.8 ± 2.9 kg), with an ETD of −1.7 ± 0.2 kg ( p = 0.007), that was more pronounced in participants ≥ 55 years (−2.6 ± 3.3 kg), paralleled by significant reductions in body mass index and hip circumference. The primary endpoint was the estimated treatment difference (ETD) in change of body weight after 3 months of treatment. Pre-tests demonstrated that the two bread types strongly differed in the glucose and insulin response elicited, but had similar energy content, texture and taste. Overweight adult volunteers ( n = 80) were randomised 1:1 to exchange previously consumed breads for either a rye bread from milled whole grain (control) or a medium-carbohydrate, low-insulin-stimulating bread (intervention). In a single-centre triple-blind randomised controlled trial the effects of two different breads on body weight were analyzed without further lifestyle modification. Our approach was to change only one component, namely bread, common to most diets. The impact on body weight development is usually analysed by comparing different diet types. Recognition of Reviewers: reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.This journal in the second half of 2022). To publication is undertaken in 2.9 days (median values for papers published in Rapid Publication: manuscripts are peer-reviewed and a firstĭecision is provided to authors approximately 15.6 days after submission acceptance.Journal Rank: JCR - Q1 ( Nutrition & Dietetics) / CiteScore - Q1 ( Food Science).High Visibility: indexed within Scopus, SCIE (Web of Science), PubMed, MEDLINE, PMC, Embase, PubAg, AGRIS, and other databases.Open Access- free for readers, with article processing charges (APC) paid by authors or their institutions.The Asia Pacific Nutrigenomics Nutrigenetics Organisation (APNNO), Italian Society for Pediatric Nutrition and Gastroenterology (SIGENP), Nutrition Society of New Zealand (NSNZ), The Nutrition Society of Australia (NSA), Ocular Wellness & Nutrition Society (OWNS) and others are affiliated with Nutrients and their members receive a discount on article processing charges. Is a peer-reviewed, open access journal of human nutrition published semimonthly online by MDPI.
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